Ultrasound triggers bone cell mobility

ScienceDaily (July 17, 2012) ? Research led by Yi-Xian Qin, PhD, Professor, Department of Biomedical Engineering, and Director of the Orthopaedic Bioengineering Research Laboratory at Stony Brook University, demonstrated that the use of medium-intensity focused ultrasound on osteoblasts, known as bone-forming cells, stimulates the mobility of the cells and triggers calcium release, a process that promotes growth. The technique could provide a foundation for a method to develop non-pharmacologic treatments of osteoporosis, fractures, and other conditions involving bone loss.

Musculoskeletal tissues, like bone and muscle, have a robust state of dynamic equilibrium in response to mechanical loading and respond to significant stimuli, such as exercise. Dr. Qin and Stony Brook colleagues Drs. Shu Zhang and Jiqi Cheng are investigating how osteoblasts (a bone-forming cell) respond to mechanical signals, such as ultrasound. In laboratory models of murine cells, the research team created a unique method to apply an ultrasound form called acoustic radiation force (ARF) for only one minute on a single osteoblastic cell and groups of cells. They consistently found that ARF through focused ultrasound beam induced cellular cytoskeletal rearrangement, the motility and mobility of the cells, and accelerated intracellular calcium transportations and concentrations.

Dr. Qin's previous findings with ultrasound include the creation of an ultrasound bone scanning device that is more advanced than existing ultrasound technology and assesses bone parameters beyond mineral density. The device is being developed as a diagnostic tool to predict early bone loss. Dr. Qin and his research team is investigating ways to combine this potential diagnostic tool with the ARF technology in the laboratory to identify bone loss and fracture within a bone region, then provide treatment via ARF to promote growth and healing.

The research projects are supported in part by the National Institutes of Health, and the National Space Biomedical Research Institute through a NASA Cooperative Agreement.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by Stony Brook Medicine.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. Shu Zhang, Jiqi Cheng, Yi-Xian Qin. Mechanobiological Modulation of Cytoskeleton and Calcium Influx in Osteoblastic Cells by Short-Term Focused Acoustic Radiation Force. PLoS ONE, 2012; 7 (6): e38343 DOI: 10.1371/journal.pone.0038343

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/5WPAFqxqvuo/120717182959.htm

kansas state last house on the left last house on the left rich forever mixtape blow the unit bob weston